This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Nakashima, Y. Articles by Kuroiwa, A. Search for Related Content PubMed PubMed Citation Articles by Nakashima, Y. Articles by Kuroiwa, A. Social Bookmarking                         What's this?

Chronic Arterial Occlusion with PGE1-Resistant Skin Lesions Treated by Glycosaminoglycan Compound—Case Reports

Second Department of Internal Medicine, University of Occupational and Environmental Health Japan, School of Medicine, Kitakyushu, Japan

Jun Segawa

Second Department of Internal Medicine, University of Occupational and Environmental Health Japan, School of Medicine, Kitakyushu, Japan

Takashi Kawashima

Second Department of Internal Medicine, University of Occupational and Environmental Health Japan, School of Medicine, Kitakyushu, Japan

Yasunori Fukuchi

Second Department of Internal Medicine, University of Occupational and Environmental Health Japan, School of Medicine, Kitakyushu, Japan

Akio Kuroiwa

Second Department of Internal Medicine, University of Occupational and Environmental Health Japan, School of Medicine, Kitakyushu, Japan

The authors report on 2 patients with chronic arterial occlusion in whom the intravenous administration of the glycosaminoglycan compound FPFD 101 was markedly effective. One patient suffered from thromboembolic episodes of the left hand, and the other had peripheral circulatory impairment related to colla gen disease. In these patients, the oral administration of anticoagulants and antiplatelet agents in combination with intravenous infusion of prostaglandin E₁ was not adequately effective. However, the addition of intravenous injection of FPFD 101 resulted in a marked improvement in their symptoms. FPFD 101, which has an anticoagulant effect and also inhibits platelet aggregation, seems to be useful for the treatment and prevention of chronic arterial occlusion when combined with drugs such as anticoagulants, antiplatelet agents, and vasodila tors.

Angiology, Vol. 41, No. 9, 731-736 (1990)
DOI: 10.1177/000331979004100908


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?