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Angiology
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Thrombolytic Versus Fibrinogenolytic Activity of rt-PA and Streptokinase in Patients with Acute Myocardial Infarction

Domenico Prisco

Clinica Medica I, University of Florence, Florence, Italy

Francesco Bonechi

Clinica Medica I, University of Florence, Florence, Italy

Luca Scarti

Clinica Medica I, University of Florence, Florence, Italy

Manuela Tramontana

Clinica Medica I, University of Florence, Florence, Italy

Rosanna Abbate

Clinica Medica I, University of Florence, Florence, Italy

Gian Franco Gensini

Clinica Medica I, University of Florence, Florence, Italy

In this study the concentration of plasma breakdown products of cross-linked fibrin (XDP), serum fibrinogen-fibrin degradation products (FDP), and plasma fibrinogen were measured before and at the end of the administration of single-chain recombinant tissue-type plasminogen activator (rt-PA, 100 mg IV over three hours) or streptokinase (1.5 million units over one hour), respectively, in two groups, each composed of 22 patients with acute myocardial infarction. The XDP concentration was not statistically different between the two groups at the end of thrombolytic treatment, whereas FDP and fibrinogen concentrations were significantly different (FDP: streptokinase 396 ± 287 vs rt-PA 177 ± 222 µg/mL, p < 0.01; fibrinogen: streptokinase 71 ± 43 vs rt-PA 181 ± 49 mg/dL, p < 0.001). These results indicate that the two drugs have equipotent thrombolytic activity at this administration regimen but that rt-PA causes a markedly more selective lysis of fibrin in comparison with streptokinase.

Angiology, Vol. 41, No. 8, 616-620 (1990)
DOI: 10.1177/000331979004100805
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