This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Takeuchi, Y. Articles by Juji, T. Search for Related Content PubMed PubMed Citation Articles by Takeuchi, Y. Articles by Juji, T. Social Bookmarking                         What's this?

HLA-D Region Genomic Polymorphism Associated with Takayasu's Arteritis

From the Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Kazumasa Matsuki

From the Blood Transfusion Service, Tokyo University Hospital, Tokyo, Japan

Yoshimi Saito

From the Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Tsuneaki Sugimoto

From the Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Takeo Juji

From the Blood Transfusion Service, Tokyo University Hospital, Tokyo, Japan

Takayasu's arteritis, with a strong predilection for women and particular geographic areas, has revealed significant association with human lymphocyte antigens (HLA) specificities. In the present study, the authors investigated for the first time the association of Takayasu's arteritis and HLA at the genomic level. By use of a restriction endonuclease Taq-I and a DQA cDNA probe, HLA-D region restriction fragment length polymorphism was examined in 32 Japanese patients. It was revealed that 65.6% of the patients shared a 6.6 kb fragment, although this fragment was found in 35.3% of the healthy Japanese (Chi square: 6.07, p < 0.02). This finding suggests that HLA-D region gene variations determine susceptibility to Takayasu's arteritis.

Angiology, Vol. 41, No. 6, 421-426 (1990)
DOI: 10.1177/000331979004100601


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?