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Angiology
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Platelet Aggregation Is Not Necessary for Occurrence of Raynaud's Phenomenon: A Clinical History and Laboratory Results

S. Bellucci

Department of Angiohematology, Lariboisiere Hospital

A. Kedra

Department of Physiology and Functional Explorations, Lariboisiere Hospital, Paris, France

P. Bray

Department of Angiohematology, Lariboisiere Hospital

J.P. Caen

Department of Angiohematology, Lariboisiere Hospital

"Raynaud's phenomenon (R.P.) is characterized by a spastic vasoconstric tion of hand and/or feet extremities leading to painful ischemic attacks. In the pathogeny of this syndrome the role of a platelet hyperactivation was evidenced. Nevertheless, the responsibility of platelet aggregation remains controversial. We report here the case of a patient presenting with a Glanzmann thrombasthenia defined by the complete lack of platelet aggregation, and show ing a typical RP which was confirmed by the measurement of hand temperature and the decrease of digital and hand blood flow. Thus, the description of this case shows that platelet aggregation by itself is not necessary for the occurrence of RP, and encourages for therapeutic purposes the development of vasodilatators rather than platelet antiaggregants agents."

Angiology, Vol. 41, No. 11, 970-972 (1990)
DOI: 10.1177/000331979004101112
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This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
T. J. M. Cleophas and M. G. Niemeyer
Raynaud's Syndrome, an Enigma After 130 Years
Angiology, March 1, 1993; 44(3): 196 - 209.
[Abstract] [PDF]


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