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B-Mode Imaging and Histomorphometric Evaluation of Carotid Atherosclerosis

Istituto di Anatomia ed Istologia Patologica Universita' di Siena, Siena

G. Bianciardi

Istituto di Anatomia ed Istologia Patologica Universita' di Siena, Siena

L. Centi

Istituto di Anatomia ed Istologia Patologica Universita' di Siena, Siena

M. Salvi

Istituto di Anatomia ed Istologia Patologica Universita' di Siena, Siena

G. Weber

Istituto di Anatomia ed Istologia Patologica Universita' di Siena, Siena

A. Susta

Istituto di Clinica Medica , Universita' di Perugia, Perugia

G. Ciuffetti

Istituto di Clinica Medica , Universita' di Perugia, Perugia

M. Mercuri

Istituto di Clinica Medica , Universita' di Perugia, Perugia

L. Parnetti

Istituto di Clinica Medica , Universita' di Perugia, Perugia

V. Senin

Istituto di Clinica Medica , Universita' di Perugia, Perugia

A. Tazza

Istituto di Clinica Chirurgica, Universita' di Perugia, Perugia, Italy

L. Moggi

Istituto di Clinica Chirurgica, Universita' di Perugia, Perugia, Italy

The quantitative and qualitative evaluation of atherosclerotic lesions by the ultrasonography has presented several problems, above all, the determination of accuracy and reproducibility of this methodology in humans. The present study aims to evaluated the results of B-mode imaging of extracranial carotid arteries in patients selected for surgery as compared with histologic results of the observations of the samples obtained by endarterectomy. Shrinkage effects of the histologic samples were taken into consideration. Several bidimensional images of atherosclerotic lesions, as obtained by ultrasound at different incident angles, were used to establish their maximum thickness. The maximum degree of the vessel stenosis calculated by ultrasound showed a high correlation (Y=0.47X+42.4, se=0.11, r=0.5, p<0.001) compared with the one obtained by histology. The imaging methodology provided however, a mean overestima tion of the stenosis of about 7%. Relationships among the amount of calcium (p<0.03); necrotic core p<0.056); and echogenic types, ie, soft, mixed, and hard; have been suggested by a statistical trend. The results suggested that of the vascular lumen due to advanced atherosclerotic lesions. Qualitative inter pretation of atherosclerosis by B-mode imaging, ie, morphologic characteristics, seem, at present, to be of value, but more investigations in depth are needed.

Angiology, Vol. 41, No. 11, 908-914 (1990)
DOI: 10.1177/000331979004101103


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