This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Rudofsky, G. Articles by Werner, H.-J. Search for Related Content PubMed PubMed Citation Articles by Rudofsky, G. Articles by Werner, H.-J. Social Bookmarking                         What's this?

Intravenous Treatment of Chronic Peripheral Occlusive Arterial Disease: A Double-Blind, Placebo-Controlled, Randomized, Multicenter Trial of Pentoxifylline

Department of Internal Medicine, University Ulm, Ulm, West Germany

K.F. Haussler

Vascular Surgery Department, Kreiskrankenhaus (District Hospital) Ammerland, Westerstede, West Germany

H.P. Künkel

Vascular Surgery Department, Kreiskrankenhaus (District Hospital) Eutin, Mühlenberg-Klinik, Malente, West Germany

H. Schneider-May

Surgical Department, Evang. Krankenhaus (Lutheran Hospital) Lütgendortmund, Dortmund, West Germany

F. Spengel

Medical Policlinic, University Munich, München, West Germany

O. Symann

Department of Internal Medicine, Marienhospital Borghorst, Steinfurt, West Germany

H.-J. Werner

IVth Department of Internal Medicine, Städt. Krankenhaus (Municipal Hospital) Frankfurt-Höchst, Frankfurt/M, West Germany

A multicenter, prospective, pla cebo-controlled, double-blind trial was conducted to investigate the effi cacy of intravenous infusion therapy with pentoxifylline over fourteen days in patients suffering from angio graphically confirmed chronic pe ripheral occlusive arterial disease, Fontaine stage II, with at least a six- month history. After a washout phase of one week, the patients received in accordance with a randomization scheme either an i.v. infusion of 300 mg of pentoxifylline (15 mL am poules) or 15 mL of a 0.9% NaCl so lution in 250 mL of 5% laevulose, administered over three hours twice daily. The main efficacy parameters were treadmill-assessed initial claudi cation distance (ICD) and absolute claudication distance (ACD). Base line testing revealed a mean ICD of 131 m in the pentoxifylline group and 126 m in the placebo cohort; mean ACD values were 239 m and 225 m respectively. The group of patients treated with pentoxifylline (n=75) displayed a significantly greater im provement (p < 0.0001) in ICD (+70%) and ACD (+60%) than the placebo group did (+33% and 32%, respectively) (n=79). The infusions were well tolerated in both groups.

Angiology, Vol. 40, No. 7, 639-649 (1989)
DOI: 10.1177/000331978904000706


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?