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Angiology
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Effects of Two Cocktails on Left Ventricular Diastolic Function in Normal Men

L. Gould

Methodist Hospital, Department of Medicine, Brooklyn, New York

T. Vacek

Methodist Hospital, Department of Medicine, Brooklyn, New York

R. Muller

Methodist Hospital, Department of Medicine, Brooklyn, New York

M. Taddeo

Methodist Hospital, Department of Medicine, Brooklyn, New York

R. Betzu

Methodist Hospital, Department of Medicine, Brooklyn, New York

The effects of alcohol on diastolic function in normal males are unknown. Therefore, 12 male physicians had a Doppler echocardiogram performed in order to assess left ventricular diastolic performance. They then drank 4 ounces of whiskey, and forty-five minutes later a repeat Doppler echocardiogram was obtained. All the Doppler indexes of diastolic performance differed significantly after the ingestion of alcohol. The mean control D-F interval was 203±26 ms and after alcohol it was 237±51 (p < 0.01). The mean control EF slope was 4.4±0.35 m/s2 and after alcohol it was 3.2±0.73 (p < 0.01). The control E-F interval was 114 ±30 ms and it increased after alcohol to 150±37 (p < 0.001). The mean control E wave was 0.54±0.10 m/s and after alcohol it was 0.43±0.07 (p < 0.01). The mean control A wave was 0.30±0.04 m/s and after alcohol it was 0.35±0.04 (p < 0.01). The mean control E/A ratio was 1.80±0.20 and it fell to 1.25±0.23 after alcohol ingestion (p < 0.001). Thus, the results suggest that 4 ounces of whiskey can produce, in normal males, a significant impairment in diastolic function.

Angiology, Vol. 40, No. 7, 613-619 (1989)
DOI: 10.1177/000331978904000702
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