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Clinical Significance of Cerebral Aneurysm in Renovascular Hypertension due to Fibromuscular Dysplasia: Two Cases in Siblings

Yasuyoshi Ouchi

Department of Internal Medicine, Mitsui Memorial Hospital

Hitoshi Tagawa

Department of Internal Medicine, Mitsui Memorial Hospital

Minoru Yamakado

Department of Internal Medicine, Mitsui Memorial Hospital

Riichiro Takanashi

Department of Pathology, Mitsui Memorial Hospital, Tokyo, Japan

Shigeru Tanaka

Department of Internal Medicine, Mitsui Memorial Hospital

Two cases, in siblings, of renovascular hypertension caused by fibromuscu lar dysplasia (FMD) of the renal artery associated with cerebral aneurysms are reported. Both of the cases were found to have cerebral aneurysm, as well as multiple stenotic or occluded lesions in arteries such as renal, mesenteric, celiac, and internal carotid arteries. One case died of subarachnoid hemorrhage and the other case was successfully operated on for the aneurysm. This report sug gests that FMD should be considered to be a systemic angiopathy including the cerebral artery, as well as the renal artery. Thus, cerebral angiography is rec ommended to detect the association with cerebral aneurysm, at least, in cases with multiple lesions of FMD. Occurrence of FMD in siblings also indicates that a genetic factor might be involved in the pathogenesis of FMD.

Angiology, Vol. 40, No. 6, 581-588 (1989)
DOI: 10.1177/000331978904000611
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