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Paroxysmal Supraventricular Tachycardia: Experience with Propafenone

Department of Cardiology and Cardiac Surgery, University of Naples, Naples, Italy

Mario De Paola

Department of Cardiology and Cardiac Surgery, University of Naples, Naples, Italy

Pietro Turco

Department of Cardiology and Cardiac Surgery, University of Naples, Naples, Italy

Domenico Smimmo

Department of Cardiology and Cardiac Surgery, University of Naples, Naples, Italy

Massimo Chiariello

Department of Cardiology and Cardiac Surgery, University of Naples, Naples, Italy

The authors studied the efficacy of intravenous (IV) (1.5-2 mg/kg) and oral propafenone (450 to 900 mg/day) in 16 patients with paroxysmal, sus tained, recurrent supraventricular tachycardia (SVT). In 5 patients IV propafenone was not given, because of intolerant SVT. Nine patients had Wolff-Parkinson-White syndrome.

IV propafenone immediately stopped and prevented reinduction of SVT in 9/11 patients. Oral propa fenone prevented SVT induction in 3 of 5 patients. In the 9 patients re sponsive to IV propafenone, oral pro pafenone was effective: in particular, in 6 patients SVT tachycardia was not induced by serial transesophageal pacings, and in the remaining 3 pa tients the arrhythmia was still in duced but was slower and of brief duration (3-5 seconds). In 11/12 pa tients responsive to oral propafenone the minimum effective dosage in pre venting the induction of the arrhyth mia was 600 mg/day. In only 1 patient was the dose of 450 mg/day equally effective.

Propafenone administration was not associated with major side ef fects. In conclusion, propafenone is very effective in the control of parox ysmal supraventricular tachycardia; intravenous propafenone can predict the efficacy of oral therapy.

Angiology, Vol. 40, No. 6, 563-568 (1989)
DOI: 10.1177/000331978904000608


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