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Effect of Buflomedil Chlorhydrate on Local Oxygen Delivery in Peripheral Vascular Disease

Angiology Section, Dept. of Internal Medicine, University of Perugia, Perugia, Italy

L. Pasqualini

Angiology Section, Dept. of Internal Medicine, University of Perugia, Perugia, Italy

G. Maragoni

Angiology Section, Dept. of Internal Medicine, University of Perugia, Perugia, Italy

U. Orlandi

Angiology Section, Dept. of Internal Medicine, University of Perugia, Perugia, Italy

Modifications in transcutaneous oxygen pressure (TcPO₂), induced by the administration of 3 mg/kg/day buflomedil chlorhydrate for seven days were evaluated in 12 subjects suffering from peripheral vascular disease (PVD). After the treatment a significant increase in TcPO ₂ basal values was observed in Stage III and Stage IV PVD patients (+32.2%) while a significant reduction of 12 % in the half-recovery time to basal val ues after an induced ischemia was re corded in Stage II PVD patients by the seventh day. Buflomedil did not, however, cause any significant varia tions in the ankle/arm pressure ratio or in the plethysmographic peak flow.

Angiology, Vol. 40, No. 6, 559-562 (1989)
DOI: 10.1177/000331978904000607


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