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Angiology
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Effect of Nifedipine on the Sick Sinus Syndrome

George Kouvaras

Department of Cardiology, Tzanio Hospital of Piraeus, Piraeus, Greece

George Chronopoulos

Department of Cardiology, Tzanio Hospital of Piraeus, Piraeus, Greece

Periklis Nikolaou

Department of Cardiology, Tzanio Hospital of Piraeus, Piraeus, Greece

George Sofronas

Department of Cardiology, Tzanio Hospital of Piraeus, Piraeus, Greece

Dennis Cokkinos

Department of Cardiology, Tzanio Hospital of Piraeus, Piraeus, Greece

The effect of nifedipine (N) on sinus node (SN) function was studied in 15 patients (9 males, 6 females) sixty-two to seventy-six (mean 68.1 ±11) years old, with sick sinus syndrome (SSS). SSS was characterized electrophysiologically by a prolonged corrected sinus node recovery time (CSNRT > 535 msec) and/or prolonged sinoatrial conduction time (SACT > 125 msec), assessed by applying premature atrial stimulation. Ten mg N was given sublingually, and CSNRT and SACT were again evaluated sixty minutes after N administration, and again ten minutes after 1.5 mg atropine (A) was given IV. Heart rate increased significantly after N (p < 0.005), systolic blood pressure (SBP) diminished sig nificantly (p < 0.005), and CSNRT and SACT shortened significantly (p < 0.005, p < 0.005) and became normal in 7 and 5 patients respectively. After A administration, a further significant increase of heart rate (p < 0.005) and decrease of CSNRT (p < 0.005) and SACT (p < 0.005) were observed. CSNRT and SACT became normal in 8 and 7 patients respectively. SBP remained sta ble.

Angiology, Vol. 40, No. 5, 450-457 (1989)
DOI: 10.1177/000331978904000505
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