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Comparison of the Efficacy and Safety of Quinapril vs. Captopril in Treatment of Moderate to Severe Hypertension

Center for Aging University of Alabama at Birmingham 933 South 19th Street Birmingham, Alabama 35294

The results of this multicenter double-blind comparative study in 172 patients with moderate to severe hypertension indicate that twice daily quinapril (20-80 mg/day) is signifi cantly more effective than captopril (50-200 mg/day) at reducing blood pressure. Following a minimum of four weeks of treatment, the results in evaluable patients showed a signif icantly greater reduction of diastolic blood pressure (DBP) in the quinapril group than in the captopril group (18.6 vs 15.3 mm Hg, respectively, p < 0.05). An intent-to-treat analysis using blood pressure data from all patients having values within an eight-to-sixteen-hour postdose treat ment window showed quinapril to produce a significantly greater re duction in DBP than captopril (18.2 vs 14.8 mm Hg, respectively, p = < 0.05). Throughout the course of the six-week study, quinapril consist ently showed efficacy superior to cap topril despite a faster captopril dose titration.

Angiology, Vol. 40, No. 4 part_2, 389-395 (1989)
DOI: 10.1177/000331978904000408


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