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Mechanical, Biochemical, and Structural Effects of Vitamin D Deficiency on the Chick Heart

From the Department of Thoracic and Cardiovascular Surgery, Ichilov Hospital, Tel Aviv, Israel

J. Barak

From the Department of Thoracic and Cardiovascular Surgery, Ichilov Hospital, Tel Aviv, Israel

T. Kushnir

From the School of Chemistry, Tel Aviv University, Tel Aviv, Israel

G. Navon

From the School of Chemistry, Tel Aviv University, Tel Aviv, Israel

M.S. Meyer

From the Department of Thoracic and Cardiovascular Surgery, Ichilov Hospital, Tel Aviv, Israel

S. Edelstein

From the School of Chemistry, Tel Aviv University, Tel Aviv, Israel

M. Ben Bassat

From the Department of Pathology, Beilinson Medical Center, Petach Tikva, Israel

B.A. Vidne

From the Department of Thoracic and Cardiovascular Surgery, Ichilov Hospital, Tel Aviv, Israel

The effects of vitamin D depriva tion on the chick heart were investi gated from three aspects: cardiac contractility (±dP/dT), intracellular high-energy phosphorus compounds, and structural differences. Four- week-old vitamin D-deficient chicks were divided into four groups: Group A served as the normal group and re ceived subcutaneous injections of cholecalciferol; Groups B and C were vitamin D-deficient hearts but per fused differently; Group D received daily subcutaneous injections of 5 µg of 1,25(OH) ₂D₃. When the isolated spontaneously beating hearts (modi fied Langendorff preparation) were perfused with Krebs-Henseleit (KH) solution containing a calcium concen tration of 2.5mM, the myocardial contractility of the vitamin D-defi cient hearts was significantly in creased when compared with group A. After the isolated heart had beaten for one hour, the myocardial contractility in the vitamin D-defi cient hearts was found to decline to significantly lower values. Presacri fice administration of 1,25(OH) ₂D₃ improved cardiac performance. Vita min D deficiency resulted in an en hanced rate of decline of the intracellular high-energy phosphorus compounds. No differences were found in the microscopic study. These observations suggest that vitamin D has a role in cardiac function.

Angiology, Vol. 40, No. 4, 300-308 (1989)
DOI: 10.1177/000331978904000410


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