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Angiology
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Effects of 3-Glucosaminoglycan Sulfate on Hemorheologic Parameters in Hyperlipidemic Peripheral Vascular Disease (PVD) Patients

A Preliminary Double-Blind Crossover Study

Giovanni Ciuffetti

2nd Department of Internal Medicine, Perugia University, Perugia, Italy

Michele Mercuri

2nd Department of Internal Medicine, Perugia University, Perugia, Italy

Adelaide Susta

2nd Department of Internal Medicine, Perugia University, Perugia, Italy

Graziana Lupattelli

2nd Department of Internal Medicine, Perugia University, Perugia, Italy

Leonella Pasqualini

2nd Department of Internal Medicine, Perugia University, Perugia, Italy

Rita Lombardini

2nd Department of Internal Medicine, Perugia University, Perugia, Italy

Elmo Mannarino

2nd Department of Internal Medicine, Perugia University, Perugia, Italy

The effects of 3-glucosaminoglycan sulfate on lipids and the hemorheologic parameters were observed in a preliminary double-blind crossover study in 30 hyperlipidemic peripheral vascular disease (PVD) patients. Parenteral adminis tration of the test drug was associated with a reduction in serum lipids, espe cially in triglyceride levels, and a lowering of fibrinogen, plasma viscosity, and whole blood viscosity levels. These effects justify the drug's use in the treatment of PVD, especially when associated with hypertriglyceridemia and hemorheo logic disturbances.

Angiology, Vol. 40, No. 4, 255-259 (1989)
DOI: 10.1177/000331978904000403
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