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Angiology
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Acenocoumarol and Pentoxifylline in Intermittent Claudication. A Controlled Clinical Study

Anton G. Dettori

Mario Pini

V Division of General Medicine, Ospedale Maggiore di Parma, Parma, Italy

Alfio Moratti

V Division of General Medicine, Ospedale Maggiore di Parma, Parma, Italy

Mauro Paolicelli

Servizio di Angiologia Medica, Arcispedale S. Maria Nuova, Reggio Emilia

Paolo Basevi

V Division of General Medicine, Ospedale Maggiore di Parma, Parma, Italy

Roberto Quintavalla

V Division of General Medicine, Ospedale Maggiore di Parma, Parma, Italy

Cesare Manotti

V Division of General Medicine, Ospedale Maggiore di Parma, Parma, Italy

Carmelo Di Lecce

Servizio di Angiologia Medica, Arcispedale S. Maria Nuova, Reggio Emilia

The efficacy and safety of pentoxifylline (400 mg tid orally) and aceno coumarol, administered singly or in combination, in the treatment of intermit tent claudication associated with chronic occlusive arterial disease were evaluated in a multi-center, randomized, factorial, blind clinical trial involving 146 patients.

The response to treatment was assessed by measuring pain-free walking time on the treadmill and by Doppler ankle/arm systolic pressure ratio at rest and after treadmill.

Both pentoxifylline and acenocoumarol were significantly more effective than placebo in increasing the proportion of patients who improved their per formance on the treadmill after one year of treatment. Benefit from active treatment was also apparent from the results of Doppler examinations per formed after physical exercise.

No significant differences were observed in comparing the effect of one ac tive drug versus the other or versus the combined treatment.

Five major hemorrhagic complications were registered in anticoagulated pa tients, two fatal cerebral hemorrhages and one gastrointestinal bleeding occur ring in the group treated with both active drugs.

The investigators conclude that (1) pentoxifylline is effective and safe in the treatment of patients with intermittent claudication (2) the benefits of oral anti coagulant therapy are outweighed by the risk of serious bleeding, and (3) the risk of bleeding is probably increased by the combined treatment with pentox ifylline.

Angiology, Vol. 40, No. 4, 237-248 (1989)
DOI: 10.1177/000331978904000401
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