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Angiology
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Vibrotactile Sensation and Response to Nifedipine Dose Titration in Primary Raynaud's Phenomenon

V.F. Challenor

Clinical Pharmacology Group, Southampton General Hospital and University of Southampton

D.G. Waller

Clinical Pharmacology Group, Southampton General Hospital and University of Southampton

R.A. Hayward

Institute of Sound and Vibration Research, Southampton General Hospital and University of Southampton

M.J. Griffin

Institute of Sound and Vibration Research, Southampton General Hospital and University of Southampton

O.S. Roath

University Haematology, Southampton General Hospital and University of Southampton, Southampton, England

The clinical response to two doses of sustained-release nifedipine was as sessed during a double-blind, randomized, placebo-controlled trial in 22 pa tients with primary Raynaud's phenomenon. Nifedipine at doses of 20 mg and 40 mg daily reduced the mean number of attacks by 40% compared with pla cebo with no significant differences between the two doses in the number of attacks or their severity. Unwanted effects were more common and more per sistent with the higher dose of nifedipine. Fingertip vibrotactile thresholds mea sured at 31.5 and 125 Hz were unchanged by treatment with nifedipine. There was, however, a correlation between the pretreatment threshold at 125 Hz and the response to treatment with nifedipine, the most favorable responses occur ring in patients with the lowest thresholds.

Angiology, Vol. 40, No. 2, 122-128 (1989)
DOI: 10.1177/000331978904000207
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