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Angiology
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Hypotensive Effects of Nifedipine in Patients with Primary Hyperparathyroidism: Case Reports

Yutaka Takata

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Shuichi Takishita

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Tokushi Koga

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Yae Nakao

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Ken Okamura

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Takashi Yao

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Ken Takemura

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Masatoshi Fujishima

Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Nifedipine was administered orally to 2 patients with primary hyperparathy roidism before and after parathyroidectomy. The operation lowered serum cal cium concentration and parathyroid hormone but did not alter plasma renin activity, plasma aldosterone concentration, and serum magnesium. The hypo tensive effects of nifedipine were markedly enhanced with the decrease in serum calcium concentration following parathyroidectomy. Thus, the level of serum calcium concentration may modulate the hypotensive effect of nifedipine in hu mans.

Angiology, Vol. 40, No. 12, 1079-1082 (1989)
DOI: 10.1177/000331978904001210
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