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Angiology
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Arterial Infusion of Combination Therapy Using Dibutyryl Adenosine 3' , 5' -Monophosphate and Mitomycin C for Hepatocellular Carcinoma Occluding Main Portal Vein: Case Studies

Kohdoh Ishii

Department of Internal Medicine, School of Medicine, Kitasato University, Kitasato, Sagamihara, Japan

Hitomi Karube

Department of Internal Medicine, School of Medicine, Kitasato University, Kitasato, Sagamihara, Japan

Hisao Shibata

Department of Internal Medicine, School of Medicine, Kitasato University, Kitasato, Sagamihara, Japan

Haruya Okabe

Department of Internal Medicine, School of Medicine, Kitasato University, Kitasato, Sagamihara, Japan

Masahiko Okudaira

Masaharu Tsuchiya

Intraarterial infusion therapy combining dibutyryl adenosine 3',5' monophosphate and mitomycin C was administered to 8 patients with hepato cellular carcinoma occluding the main portal vein. Three patients survived more than nine months, including 1 who has been well for forty-eight months with technical imaging showing complete regression. A decreased level of serum {alpha}-fetoprotein of more than 90% was obtained in 38% of patients. Causes of death included hepatic failure, rupture of esophageal varices, acute gastric ul cer, and cerebral hemorrhage. It is concluded that the combination therapy may be useful for HCC.

Angiology, Vol. 40, No. 12, 1072-1078 (1989)
DOI: 10.1177/000331978904001209
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