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Angiology
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Therapeutic, Hemodynamic, and Metabolic Effects of Hyperbaric Oxygenation in Peripheral Vascular Disease

Adriana Visonà

Istituto di Medicina Clinica, University of Padova

Luigi Lusiani

Istituto di Medicina Clinica, University of Padova

Fabrizio Rusca

Istituto di Anestesia e Rianimazione, University of Padova

Damiano Barbiero

Istituto di Medicina Clinica, University of Padova

Fulvio Ursini

Istituto di Chimica Biologica, University of Padova, Padova, Italy

Antonio Pagnan

Istituto di Medicina Clinica, University of Padova

Hyperbaric oxygen therapy (HBT) consists of inhaling 100% oxy gen under pressure exceeding atmos pheric pressure.

Patients with various degrees of peripheral vascular disease (stages II, III, and IV according to Fontaine's classification) were treated with HBT. Clinical symptoms improved in 70%. Ankle/brachial index increased by more than 0.10 in 47%. Photo plethysmographic pulse appearance has been detected in roughly one third of patients. Transcutaneous ox ygen tension did not, however, im prove significantly. Plasma malon dialdehyde (MDA) was evaluated as a marker of lipid peroxidation, possi bly influenced by hyperbaric oxygen. Surprisingly, the authors found that MDA levels decreased after HBT, probably as a result of the activation of antioxidant systems. These results show that HBT represents a useful approach in the treatment of periph eral vascular disease, since it im proves clinical and hemodynamic parameters, with no potentially harmful side effects, such as en hanced lipid peroxidation, at least in the short term.

Angiology, Vol. 40, No. 11, 994-1000 (1989)
DOI: 10.1177/000331978904001110
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