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Monoclonal Antibody—Defined Lymphocyte Subsets in Normal Nigerians

Department of Hematology, College of Medical Sciences, University of Benin, Benin City, Nigeria

Lymphocyte subsets using monoclonal antibodies have hitherto not been re ported in normal Nigerian subjects. In all 8 subjects, the average number of lymphocytes showed a clear rhythmicity with higher values in the morning (8 AM) than in the afternoon (2 PM). The time of day variation in circulating lymphocytes appears to affect T cells rather than B cells. The absolute numbers of 0KT4+ cells at 8 AM was significantly higher than at 2 PM (p < 0.05).

It would appear that the 0KT4+ cells are largely responsible for the time of day variation in peripheral blood lymphocytes, owing probably to a greater sensitivity to changes in plasma cortisol levels.

Angiology, Vol. 40, No. 11, 977-981 (1989)
DOI: 10.1177/000331978904001107


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