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S-Mg Does Not Change Inversely to S-FFA During Acute Stress Situations

Department of Medicine, Section of Cardiology, Malmö General Hospital, Malmö, Sweden

Bengt W. Johansson

Department of Medicine, Section of Cardiology, Malmö General Hospital, Malmö, Sweden

The apparently divergent changes in serum magnesium (S-Mg) and serum free fatty acids (S-FFA) in stress situations associated with ele vated levels of circulating adrenaline were studied experimentally in 12 healthy volunteers, who were each given three adrenaline infusions (0.05 µg/kg bw/min over one hundred twenty minutes). Before the adrena line infusions the volunteers were treated for three days with either a non-selective beta-blocking agent (propranolol) or a beta-1-selective agent (atenolol) or with placebo.

Six of the volunteers underwent a fourth adrenaline infusion after pretreatment with a beta-2-selective beta-blocking agent (ICI 118551). S- Mg and S-FFA were determined every fifteen minutes. After pretreatment with placebo, adrenaline infusion caused an increase in S-FFA from 0.22 ± 0.20 mmol/L (mean ± SD) to max 0.59 ± 0.39 mmol/L after thirty minutes of adrenaline infusion (p < 0.001). At one hundred twenty minutes S-FFA had decreased to 0.35 ± 0.26 mmol/L. Thirty minutes after cessation of the adrenaline infusion, S-FFA had returned to the same level as before the infusion. S-Mg before the adrenaline infusion was 0.83 ± 0.05 mmol/L, rose to 0.85 ± 0.05 at fifteen minutes, and then decreased to 0.78 ± 0.05 at one hundred thirty- five minutes (p < 0.05). Pretreat ment with atenolol did not change this pattern, although the changes in S-FFA and S-Mg were of a smaller magnitude but still statistically sig nificant. No statistically significant changes in S-FFA or S-Mg were seen after pretreatment with either pro pranolol or ICI 118551.

The results show that the adrena line-induced changes in S-FFA and S-Mg disappear after blockade of the beta-2-adrenoceptor. The changes in S-FFA were not opposite to the changes in S-Mg, and although the changes in S-Mg could be explained in part by a binding of Mg to FFA in serum, there are probably other mechanisms at work too, such as a transport from the extracellular to the intracellular compartment.

Angiology, Vol. 40, No. 11, 1011-1019 (1989)
DOI: 10.1177/000331978904001112


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