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Angiology
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Effects of Calcium Antagonists and Nitroglycerin on Atrial Natriuretic Peptide in Normal Subjects and Patients with Essential Hypertension

Tsutomu Iwasaki, M.D.

Departments of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumoto, Nagano, Japan

Akihiro Niwa, M.D.

Departments of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumoto, Nagano, Japan

Toshio Shinoda, M.D.

Departments of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumoto, Nagano, Japan

Masaki Ishihara, M.D.

Departments of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumoto, Nagano, Japan

Toru Aizawa, M.D.

Departments of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumoto, Nagano, Japan

Takashi Yamada, M.D.

Departments of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumoto, Nagano, Japan

Acute effects of coronary vasodilators (nifedipine, nicardipine, and nitroglycerin) on atrial natriuretic peptide (ANP) and the renin-angiotensin-aldosterone system were studied in normal subjects and patients with essential hypertension. Nifedipine lowered blood pressure both in normal subjects and in patients and elevated ANP, plasma renin activity, and angiotensin II in normal subjects but not in hypertensive patients. Nicardipine lowered blood pressure but failed to elevate ANP and angiotensin II in normal subjects. Nitroglycerin failed to elevate ANP in normal subjects.

Angiology, Vol. 40, No. 1, 24-28 (1989)
DOI: 10.1177/000331978904000105
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