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Arteriovenous Anastomoses' Function and Raynaud's Phenomenon

Institute of Medical Clinic I, Chair of Angiology, University of Florence, Florence, Italy

Enrico Pesciullesi

From the Nuclear Medicine Unit, USL 10/D, Florence, Italy

Franco Lucarelli

Institute of Medical Clinic I, Chair of Angiology, University of Florence, Florence, Italy

Eleonora Lucente

Institute of Medical Clinic I, Chair of Angiology, University of Florence, Florence, Italy

Paolo Ferri

From the Nuclear Medicine Unit, USL 10/D, Florence, Italy

Argene Patrizia Tonarelli

Institute of Medical Clinic I, Chair of Angiology, University of Florence, Florence, Italy

Daniele Righi

Institute of Medical Clinic I, Chair of Angiology, University of Florence, Florence, Italy

Nicola Mangoni

Institute of Medical Clinic I, Chair of Angiology, University of Florence, Florence, Italy

By intrabrachial artery injections of a bolus of human albumin microspheres labeled with ⁹⁹ mTc in patients with primary or secondary Raynaud's phenome non (RP) and in a group of healthy volunteers, the authors developed a method of detecting the patency rate of arteriovenous anastomoses (AVA) in the hand, after local heat and cold stimulation, by quantifying the radioactivity of the lungs expressed as a percentage of an intravenously injected radionuclide dose. With strain gauge plethysmography, simultaneous changes in the digital total (DTF) flow were also measured. After exposure of fingers to cold, 25 of 26 subjects had a clear reduction in both DTF and the AVA patency rate (APR) in comparison with the corresponding heat values. The RP patients, in particular, showed a statistically significant reduction in DTF (P < 0.001) and in APR (P < 0.001).

These results appear to be consistent with the onset of critically reduced patency of the AVA of the hand during the ischemic phase of RP.

Angiology, Vol. 39, No. 9, 812-818 (1988)
DOI: 10.1177/000331978803900905


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