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Altered in Vitro Hemostasis, Clotting, and Thrombolysis After Oral Nifedipine in Normal Volunteers

St. Bartholomew's Centre for Research and Department of Dermatology, St. Bartholomew's Hospital, London

Richard H. Meyrick-Thomas

St. Bartholomew's Centre for Research and Department of Dermatology, St. Bartholomew's Hospital, London

John D. T. Kirby

St. Bartholomew's Centre for Research and Department of Dermatology, St. Bartholomew's Hospital, London

Iren B. Kovacs

St. Bartholomew's Centre for Research and Department of Dermatology, St. Bartholomew's Hospital, London

In this study the authors used the Haemostatometer, a new instrument to monitor the pattern of hemostatic plug formation that occurs in holes in poly ethylene tubing through which nonanticoagulated blood is flowing under stand ard conditions. The pattern and speed of blood coagulation, subsequent to hemostasis, was also monitored. Simultaneously, the time until expulsion of he mostatic plugs formed was measured and considered as spontaneous thrombo lysis time (STT). In 10 healthy volunteers, blood samples were drawn and tested before and ninety minutes after administration of 10 mg oral nifedipine. After nifedipine, the initial phase of primary hemostasis was delayed (p < 0.05), the clotting time lengthened (p < 0.01), and the STT shortened (p < 0.01). The au thors conclude that the effect of nifedipine on hemostasis and thrombolysis could contribute to its therapeutic efficacy.

Angiology, Vol. 39, No. 8, 747-751 (1988)
DOI: 10.1177/000331978803900807


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