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Hemorheologic Treatment of Cerebral Reversible Ischemic Episodes with Pentoxifylline — A Prospective Study

Department of Neurology, University of Graz, Graz, Austria

E. Körner

Department of Neurology, University of Graz, Graz, Austria

H. Lechner

Department of Neurology, University of Graz, Graz, Austria

One hundred patients (49 males, 51 females) with reversible neurologic defi cit due to cerebral ischemia of vascular origin in the carotid artery territory were recruited for a long-term observation to follow up recurrence of ischemic events. Fifty-eight patients (mean age sixty-four years) were treated daily with 1200 mg oral pentoxifylline in addition to basic therapy (antihypertensives, antidiabetic drugs, etc), and 42 matching patients (mean age sixty-two years) of a control group had no pentoxifylline or other hemorheologic medication. The mean observation period was fifty-six months (range thirty-six to sixty). On admission patients presented with increased platelet aggregation and/or im paired red cell filterability and with enhanced red cell aggregation. Five pa tients in the pentoxifylline group (8.6%) and 16 control patients (38%) suffered a relapse of an ischemic episode. These data support previous reports of a bene ficial effect of pentoxifylline in the prevention of cerebral ischemic events.

Angiology, Vol. 39, No. 6, 520-525 (1988)
DOI: 10.1177/000331978803900605


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