SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Angiology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Asai, K.
Right arrow Articles by Kuzuya, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Asai, K.
Right arrow Articles by Kuzuya, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Effects of Splenectomy on Serum Lipids and Experimental Atherosclerosis

Kanichi Asai

Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan

Masafumi Kuzuya

Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan

Michitaka Naito

Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan

Chiaki Funaki

Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan

Fumio Kuzuya

Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan

The authors examined the effects of splenectomy on serum lipids in patients with hematologic disease, in rabbits, and also in cholesterol-fed rabbits with experimental atherosclerosis.

Serum cholesterol was determined in patients with hypersplenism before and after splenectomy. Meanwhile serum lipids were determined in two groups of rabbits: splenectomy group (Spx group, n = 19), and sham operation group (Sham group, n = 14) before and after the operation. Then the rabbits were divided into four subgroups: cholesterol-fed groups-Spx-C (n = 12) and Sham- C (n=9), and normal-chow-fed groups-Spx-N (n=7) and Sham-N (n=5). The Spx-C and the Sham-C rabbits were fed 1% cholesterol diet and the Spx-N and the Sham-N rabbits were fed normal chow for twelve weeks. In patients preop erative serum cholesterol levels were low, and significant increase in serum cho lesterol was observed following splenectomy. In rabbits, the Spx-C group showed significantly higher levels of serum cholesterol, triglycerides, and phos pholipids in contrast to lower levels of high density lipoprotein cholesterol, as compared with the Sham-C group. The percentage of aortic plaque area in the Spx-C group tended to be higher than that in the Sham-C group. On the other hand, the Spx-N and the Sham-N group showed no difference in serum lipids during twelve weeks. The worsening of atherosclerosis in the Spx-C group was considered to be mainly due to an enhanced hyperlipidemia.

Their results suggest a possible role of the spleen in lipid metabolism, in particular the existence of a splenic factor that can cause hypocholesterolemia in hyperplenism and can suppress hyperlipidemia.

Angiology, Vol. 39, No. 6, 497-504 (1988)
DOI: 10.1177/000331978803900602
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




Advertisement