This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Johansson, B. W. Articles by Svensson, O. Search for Related Content PubMed PubMed Citation Articles by Johansson, B. W. Articles by Svensson, O. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB DILTIAZEM EPINEPHRINE VERAPAMIL HYDROCHLORIDE Social Bookmarking                         What's this?

Adrenaline-Induced Changes in Serum Electrolytes, ECG, and Blood Pressure, with Ca-Blockade Pretreatment

Section of Cardiology, Malmö General Hospital, Malmö, Sweden

Ole Hansen, M.D.

Section of Cardiology, Malmö General Hospital, Malmö, Sweden

Steen Juul-Möller, M.D.

Section of Cardiology, Malmö General Hospital, Malmö, Sweden

Ola Svensson, M.D.

Section of Cardiology, Malmö General Hospital, Malmö, Sweden

Adrenaline infusions (AI) (0.5 µg adrenaline per 10 kg body weight per minute over 120 minutes) were given weekly for three weeks to 20 healthy male volunteers aged twenty-one to thirty-eight years. The AI was given after three days' treatment with diltiazem (D), verapamil (V), or placebo (Pl) in a single-blind fashion. After pretreatment with PI, serum potassium (s-K) decreased from 3.93 ± 0.30 mmol/L (M ± SD) to 3.33 ± 0.31 (P < 0.001) with the greatest change 69.75 ± 46.24 minutes after the start of the AI. Corresponding values for s-Mg were 0.84 ± 0.06 to 0.78 ± 0.05 (P < 0.01) and 106.50 ± 36.71 minutes, for s-Ca 2.40 ± 0.07 to 2.30 ± 0.08 (P < 0.01) and 103.50 ± 36.06 minutes, for s-P 1.05 ± 0.17 to 0.91 ± 0.17 (P < 0.02) and 80.25 ± 47.25 minutes, and for s-urate 344.79 ± 50.55 to 329.26 ± 47.80 (P > 0.05) and 63.95 ± 46.05 minutes. After pretreatment with D, AI produced similar electrolyte changes as after PI, but the rise in blood glucose was slightly more pronounced and the drop in s-urate less pronounced. The heart rate (HR) before AI after pretreatment with D was lower than after PI, but the increase during the AI was of the same magnitude. The AI-induced changes in systolic (SBP) and diastolic (DBP) blood pressure after D did not differ significantly from those seen after PI, and neither did QT and QT_c, whereas the PR duration was prolonged (0.18 ± 0.03 second) when compared with PI (0.16 ± 0.02) (P < 0.05). Although the magnitude of the change in DBP was not influenced, V prolonged the time till the lowest DBP (48.95 ± 26.38 minutes) when compared with PI (31.50 ± 29.16 minutes) (P > 0.05). The other variables followed the same pattern as for D.

In conclusion AI in healthy volunteers produced a drop in s-K but in addition a drop in s-Mg and s-Ca, the latter appearing later than the drop in s-K. Pretreatment with diltiazem and verapamil did not influence the magnitude of these changes but reduced the drop in s-urate.

Angiology, Vol. 39, No. 4, 345-354 (1988)
DOI: 10.1177/000331978803900403


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				O. Hansen, B. W. Johansson, and B. Gullberg Metabolic, Hemodynamic, and Electrocardiographic Responses to Increased Circulating Adrenaline: Effects of Pretreatment with Class 1 Antiarrhythmics Angiology, December 1, 1991; 42(12): 990 - 1001. [Abstract] [PDF]

				O. Hansen, B. W. Johansson, and P. Nilsson-Ehle Metabolic, Electrocardiographic, and Hemodynamic Responses to Increased Circulating Adrenaline: Effects of Selective and Nonselective Beta Adrenoceptor Blockade Angiology, March 1, 1990; 41(3): 175 - 188. [PDF]

				O. Hansen and B. W. Johansson S-Mg Does Not Change Inversely to S-FFA During Acute Stress Situations Angiology, November 1, 1989; 40(11): 1011 - 1019. [Abstract] [PDF]