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Angiology
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No Metabolic Side Effects of Long-Term Treatment with Verapamil in Hypertension

Kjell Midtbø

From the Medical Department, Section of Cardiology, Ullevaal Hospital, Oslo, Norway

Oddveig Lauve

Ottar Hals

From Norsk Hydro Ltd., Oslo, Norway

In a prospective, open study 45 patients (mean age fifty-three years) with essential hypertension were treated with verapamil for four to eight years (mean 5.3 years). Blood pressure was satisfactorily controlled (from 160/104 to 145/91) and the side effects were infrequent, mild, and often transient. Verapamil did not exert any unfavorable metabolic or hematologic effects over the years. HDL-cholesterol was moderately increased (mean 24%) and the other plasma lipids were unaffected. These data suggest that the calcium channel blocker verapamil is a metabolically safe drug to use as monotherapy in essential hyper tension.

Angiology, Vol. 39, No. 12, 1025-1029 (1988)
DOI: 10.1177/000331978803901204
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