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Angiology
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Opening of Coronary Collaterals by Repeated Brief Coronary Occlusions in Conscious Dogs

Masatoshi Fujita

Dalton Research Center, University of Missouri-Columbia, Columbia, Missouri

Daniel P. McKown

Dalton Research Center, University of Missouri-Columbia, Columbia, Missouri

Michael D. McKown

Dalton Research Center, University of Missouri-Columbia, Columbia, Missouri

Dean Franklin

Dalton Research Center, University of Missouri-Columbia, Columbia, Missouri

The collateral blood flow and regional myocardial function during a one- minute coronary occlusion were compared before and after multiple one-minute coronary occlusions. After repeated coronary occlusions, the collateral blood flow velocity increased significantly from 0.7 ± 0.1 (SE) to 2.0 ± 0.2 cm/sec (p < 0.05), and the blood flow debt repayment decreased from 326±26% to 189 ± 12 % (p < 0.05). The systolic segment shortening in the collateral depend ent zone improved slightly. Thus, the native coronary collateral vessels open in response to a repeated ischemic stimulus.

Angiology, Vol. 39, No. 11, 973-980 (1988)
DOI: 10.1177/000331978803901107
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