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A New Syndrome: Angiotensin-Converting Enzyme Dysfunction Syndrome: Differential Diagnosis and Pathogenesis—Case Reports

Department of Internal Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Okayama, Japan

Akira Terao, M.D.

Department of Internal Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Okayama, Japan

Toshitami Sawayama, M.D.

Department of Internal Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Okayama, Japan

The authors previously reported a new syndrome, angiotensin-converting enzyme dysfunction syndrome (ACEDS), which is clinically characterized by mild systemic hypertension, a hypokalemic alkalosis, and hyperreninism with a high concentration of angiotensin-I (ANG-I), a normal angiotensin-II (ANG-II) value, and a normal aldosterone level. In the present study, they investigated the diagnosis and differentiation of diseases concomitant with hyperreninism, such as ACEDS, Bartter's syndrome, familial periodic paralysis, and renovascular hypertension treated with captopril for two months, and discussed the pathogenesis of ACEDS.

Angiology, Vol. 39, No. 1, 58-67 (1988)
DOI: 10.1177/000331978803900110


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