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Angiology
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Effects of Mesoglycan Sulfate on the Arterial Elastic Module

Guiseppe Maria Andreozzi

Chair of Angiology, University of Catania, Catania, Italy

Salvatore Signorelli

Chair of Angiology, University of Catania, Catania, Italy

Salvatrice Lo Duca

Chair of Angiology, University of Catania, Catania, Italy

Concetta Minacapelli

Chair of Angiology, University of Catania, Catania, Italy

Maria T. Amico-Roxas

Chair of Angiology, University of Catania, Catania, Italy

Giovanna Minardo

Chair of Angiology, University of Catania, Catania, Italy

Giuseppe Cacciaguerra

Chair of Angiology, University of Catania, Catania, Italy

Ten patients with peripheral obstructive arterial disease (POAD) in stages I and II according to Leriche-Fontaine, were subjected to therapy with mesogly can sulfate (60 mg/day for twenty days), to evaluate the effect of the drug on the elastic module of the arterial wall. The wall elasticity was deduced from some Doppler velocitographic indices (arterial dynamics index, resistance index, per fusion pressure index, tibial distensibility index); from the analysis of systolic, protodiastolic, and end diastolic velocity variations; and from computerized analysis of the Doppler sound spectrum.

The results show a significant improvement of arterial wall elasticity, which suggests a rational use for the drug in the initial stages of peripheral obstructive arterial disease.

Angiology, Vol. 38, No. 8, 593-600 (1987)
DOI: 10.1177/000331978703800803


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