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Angiology
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Nicardipine in the Treatment of Raynaud's Phenomenon: A Randomized Double-Blind Trial

André Kahan

Department of Rheumatology, Rene Descartes University, Department of Cardiology, René Descartes University, School of Medicine, Hôpital Cochin, Paris, France

Bernard Amor

Department of Rheumatology, Rene Descartes University, Department of Cardiology, René Descartes University, School of Medicine, Hôpital Cochin, Paris, France

Charles J. Menkès

Department of Rheumatology, Rene Descartes University, Department of Cardiology, René Descartes University, School of Medicine, Hôpital Cochin, Paris, France

Simon Weber

Department of Rheumatology, Rene Descartes University, Department of Cardiology, René Descartes University, School of Medicine, Hôpital Cochin, Paris, France

Francois Guérin

Department of Rheumatology, Rene Descartes University, Department of Cardiology, René Descartes University, School of Medicine, Hôpital Cochin, Paris, France

Michel Degeorges

Department of Rheumatology, Rene Descartes University, Department of Cardiology, René Descartes University, School of Medicine, Hôpital Cochin, Paris, France

The efficacy of the calcium-channel blocker nicardipine in the treatment of Raynaud's phenomenon was assessed in a prospective, double-blind, randomized, crossover trial in 20 patients. Each patient received nicardipine 20 mg or placebo three times a day for two weeks and then was crossed over for two weeks. Nicardipine significantly decreased the frequency and severity of Raynaud's phenomenon as compared with placebo. The authors conclude that nicardipine is effective in the treatment of Raynaud's phenomenon.

Angiology, Vol. 38, No. 4, 333-337 (1987)
DOI: 10.1177/000331978703800407
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