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Noninvasive Hemodynamic Assessment of Vasospasm in Patients with Primary Raynaud's Phenomenon

Clinical Vascular Laboratory, Institute of Thoracic, Cardiac and Vascular Surgery, Sint Radboud University Hospital, Nijmegen, The Netherlands

Pieter F. F. Wijn

Clinical Vascular Laboratory, Institute of Thoracic, Cardiac and Vascular Surgery, Sint Radboud University Hospital, Nijmegen, The Netherlands

Henk J. J. van Lier

From the Department of Statistical Consultation, Catholic University, Nijmegen, The Netherlands

Wim G. H. J. Kneepkens

Clinical Vascular Laboratory, Institute of Thoracic, Cardiac and Vascular Surgery, Sint Radboud University Hospital, Nijmegen, The Netherlands

Stefan H. Skotnicki

Clinical Vascular Laboratory, Institute of Thoracic, Cardiac and Vascular Surgery, Sint Radboud University Hospital, Nijmegen, The Netherlands

In order to assess vasospastic ischemic disease objectively 41 patients with primary Raynaud's phenomenon and 21 normal volunteers were investigated noninvasively by digital systolic blood pressure and digital skin temperature measurements before and after instant cold provocation. Much care had been taken to be certain that all patients had primary Raynaud's phenomenon.

The results of digital pressure measurements appeared to be affected by interindividual variations in systemic systolic blood pressure. By introducing a digit-to-brachial systolic blood pressure index (DBI), such variations could be eliminated. Instant cold provocation did not change DBI significantly. No pressure drop due to a closing phenomenon could be observed.

Both digital skin temperature and DBI differed significantly between healthy males and females. In the patient group males and females did not show significant differences. The results in healthy females were hardly different from the results in patients. Healthy males could be well discriminated from patients with both techniques. Sex differentiation appeared to be essential for the objective assessment of primary Raynaud's phenomenon.

Angiology, Vol. 38, No. 4, 315-332 (1987)
DOI: 10.1177/000331978703800406


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