This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Solvay, H. Articles by Fenollar, J.V. Search for Related Content PubMed PubMed Citation Articles by Solvay, H. Articles by Fenollar, J.V. Social Bookmarking                         What's this?

Glucose and Erythrocyte ATP: Distinctive Effects of Dipyridamole and of Ticlopidine

From the Department of Physiology, U.L.B., Free University of Brussels, Brussels, Belgium

M. Kahn

From the Department of Physiology, U.L.B., Free University of Brussels, Brussels, Belgium

S. Garreyn

From the Department of Physiology, U.L.B., Free University of Brussels, Brussels, Belgium

M. Cloarec

From the Hospital Tenon Polyclinic, C.H.U. Saint-Antoine, University of Paris VI, Paris, France

R. Sneppe

From the Department of Audiophonology, U.C.L., Catholic University of Louvain La Neuve, Louvain, Belgium

E. Schram

From the Institute of Molecular Biology, V.U.B., Free University of Brussels, Brussels, Belgium

J.V. Fenollar

From the Department of Cardiology, University of Valencia, Valencia, Spain

This experiment suggests the following points:

1. Erythrocytes in control patients and in atherosclerosis patients seem to have a variable grade of affinity for adenosine and for plasma glucose. This variable grade seems to fix the level of the adenosine triphosphate (ATP) reserves and induces the erythrocytes' deformability.

2. The drop in the level of ATP reserves that induces the poor deformability of the erythrocytes in atherosclerosis patients would appear to be caused by two consecutive shortages: first a shortage that seems to be related to a deficiency of erythrocyte adenosine as the ATP shortage disappears with dipyridamole treatment and then a shortage induced by the lack of erythrocyte glucose and suppressed by the addition of ticlopidine to the dipyridamole treatment.

Angiology, Vol. 38, No. 11, 815-824 (1987)
DOI: 10.1177/000331978703801103


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				G. Ciuffetti, G. Aisa, M. Mercuri, R. Lombardini, R. Paltriccia, C. Neri, and U. Senin Effects of Ticlopidine on the Neurologic Outcome and the Hemorheologic Pattern in the Postacute Phase of Ischemic Stroke: A Pilot Study Angiology, July 1, 1990; 41(7): 505 - 511. [Abstract] [PDF]