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Theory and Methods of Local Tissue-pO2 Monitoring in Experimental Angiology

Surgical Clinic and Policlinic, University of Münster, Münster, West Germany

J. Hauss, M.D.

Surgical Clinic and Policlinic, University of Münster, Münster, West Germany

K. Schönleben, M.D.

From the Surgical Clinic Municipal Hospital, Ludwigshafen, West Germany

H. Bünte, M.D.

From the Surgical Clinic and Policlinic, University of Münster, Münster, West Germany

The platinum-multiwire-surface electrode after Kessler and Lübbers gives the opportunity of direct measuring of the local tissue-pO₂-pressure; this 8-wire electrode with a Pt-wire-diameter of 15 µm operates on the polarographic principle. Each Pt-wire has a hemispheric collecting area of about 30 µm. Pressure ischemia by compression of capillaries is prevented by proportioning the weight (2.1 g) of the electrode.

Data output is done by 1) continuous pO₂ measuring; 2) pO₂ histograms.

During the continuous pO₂ measurement the electrode stays on the tissue measuring point thus enabling the direct record of quickly proceeding reactions. The pO ₂-histogram exhibits the statistical distribution of the local partial oxygen pressures in a studied organ, a quasi sample inquiry is performed in the tissue, based on minimum 100 single values that are obtained by repeated manual repositioning of the electrode.

By this, values are obtained on the level and distribution of local pO₂ in the tissue so that condition and function of the microcirculation can be objectively assessed. Immediate alterations in the local tissue pO₂ suggest regulatory adjustment after hemodynamic changes. Technical problems connected with pO₂ measurement in clinical use (sterilization, data acquisition and presentation) are described. The presented technique gives the chance to exactly assess the effects of vasoactive drugs on the microcirculation and to quantify the results of operations, for example after bypass-surgery.

Angiology, Vol. 38, No. 1, 1-12 (1987)
DOI: 10.1177/000331978703800101


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