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tcpO 2, Arterial Blood Flow and Lactate/Pyruvate Modifications Induced by a Single Dose of Naftidrofuryl IV During Stage III Lower-Limb Arteriopathies

Departments of Nutrition and Microbiology, University of Nancy I, Hospital Jeanne d'Arc, Toul Cedex, France

Michel Mosnier

Lipha Laboratory, Lyon, France

Gérard Percebois

Departments of Nutrition and Microbiology, University of Nancy I, Hospital Jeanne d'Arc, Toul Cedex, France

Gérard Debry

Departments of Nutrition and Microbiology, University of Nancy I, Hospital Jeanne d'Arc, Toul Cedex, France

J.P. Pointel

Service de Médecine G Hôpital Jeanne a'Arc B. P. 303 54201 Toul Cedex, France

A single dose of 600 mg of naftidrofuryl perfused IV during three hours in 12 stage III arteriopathic patients did not modify the average blood flow at the calf but did significantly increase transcutaneous oxygen pressure (33 vs 52 mmHg) and also improved lactates (1.44 vs 0.88 mmol/liter), pyruvate (59 vs 79 µmol/liter), and lactates-pyruvates ratio (33.48 vs 20.92).

Angiology, Vol. 37, No. 9, 647-653 (1986)
DOI: 10.1177/000331978603700905


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