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Efficacy and Safety of Oral Tocainide in Refractory Ventricular Arrhythmia: A Preliminary Report on an Open Label Study

Division of Cardiology, USAF Regional Hospital at Carswell and Texas College of Osteopathic Medicine, Fort Worth, Texas

Dipta Mahapatra

Division of Cardiology, USAF Regional Hospital at Carswell and Texas College of Osteopathic Medicine, Fort Worth, Texas

The preliminary data on efficacy and safety of oral tocainide in refractory ventricular dysrhythmia in 8 patients is described. Two patients died; one within 15 days and the other after 1750 days of continuous tocainide therapy. The cause of death in both patients was unclear. During initial administration and acute titration, oral tocainide was extremely effective in lidocaine-sensitive ventricular dysrhythmia and in patients with Q-T prolongation syndrome. Four out of 8 patients received tocainide in presence of left ventricular dysfunction and 2 out of 4 such patients died suddenly. Minor central nervous system side effects were seen in 2 patients and dermatologic adverse reaction was seen in one patient only.

Angiology, Vol. 37, No. 4, 285-293 (1986)
DOI: 10.1177/000331978603700404


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