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Angiology
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The Effect of ß-Blockade on Leg Blood Flow in Hypertensive Patients with Intermittent Claudication

Per-Åke Boström

From the Department of Internal Medicine, Lund University, Malmö General Hospital, Malmö, Sweden

Lars Janzon

From the Department of Surgery, Lund University, Malmö General Hospital, Malmö, Sweden

Ola Ohlsson

Department of Internal Medicine, Kristianstad Hospital, Kristianstad, Sweden

Anita Westergren

From the Department of Clinical Physiology, Lund University, Malmö General Hospital, Malmö, Sweden

The present study was designed to assess the short-term effects of ß-blocking antihypertensive treatment on leg blood flow in patients with peripheral artery disease. Seven patients with intermittent claudication were randomly allocated to treatment with atenolol 100 mg or pindolol 10 mg. Patients switched therapy after one month of treatment. Venous occlusion plethysmography on the calves was used to assess the effects on leg blood flow after one and two months of treatment. The average 10% reduction of the systolic and diastolic blood pres sures was not associated with any reduction of blood flow at rest. There was on average 3.4 ml reduction of peak flow which had no influence on the painfree or total walking distance.

Angiology, Vol. 37, No. 3, 149-153 (1986)
DOI: 10.1177/000331978603700302
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