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Aortic Connective Tissue in Atherosclerotic Aorta— A Biochemical Study

Institute of Clinical Medicine and Medical Therapy Universitá degli studi of Florence, Florence, Italy

Alessandro Bussotti

Institute of Clinical Medicine and Medical Therapy Universitá degli studi of Florence, Florence, Italy

Daniele Cammelli

Institute of Clinical Medicine and Medical Therapy Universitá degli studi of Florence, Florence, Italy

Francesco di Giovine

University of Edinburgh, Rheumatic Disease Unit, Northern General Hospital, Edinburgh, Scotland

Gaetana Sterrantino

Institute of Clinical Medicine and Medical Therapy Universitá degli studi of Florence, Florence, Italy

Giuseppe Varcasia

Institute of Clinical Medicine and Medical Therapy Universitá degli studi of Florence, Florence, Italy

Paolo Arcangeli

Institute of Clinical Medicine and Medical Therapy Universitá degli studi of Florence, Florence, Italy

Biochemical analysis of the extracellular matrix of human aortas was per formed on samples of ascending and descending aortas affected by atherosclero sis in comparison with a control group of nonatherosclerotic aortas.

Ulcerated or heavily calcified atheromas were excised and excluded from the analysis in order to differentiate biochemical alterations leading to the forma tion of atheromas from those due to complications of already formed athero mas.

Our results show that the development of atheromas brings about an exten sive destruction of elastic fibers and muscular cells, and their place is occupied by other components of the extracellular matrix, most notably, collagen, non uronic sugars, water, and lipids, which were found significantly increased.

Angiology, Vol. 37, No. 10, 735-743 (1986)
DOI: 10.1177/000331978603701007


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