This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Poggesi, L. Articles by Serneri, G. G. N. Search for Related Content PubMed PubMed Citation Articles by Poggesi, L. Articles by Serneri, G. G. N. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?

Pentoxifylline Treatment in Patients with Occlusive Peripheral Arterial Disease. Circulatory Changes and Effects on Prostaglandin Synthesis

Clinica Medica I, University of Florence, Florence, Italy

Luca Scarti

Clinica Medica I, University of Florence, Florence, Italy

Maria Boddi

Clinica Medica I, University of Florence, Florence, Italy

Giulio Masotti

Clinica Medica I, University of Florence, Florence, Italy

Gian Gastone Neri Serneri

Clinica Medica I, University of Florence, Florence, Italy

Pentoxifylline has recently been reported to stimulate in vitro the synthesis of prostacyclin. However it is not known so far whether the drug is able to stimulate prostacyclin synthesis in man also in vivo. In the present study the effects of pentoxifylline on prostaglandin synthesis and several circulatory pa rameters were studied in 10 controls and 10 patients with occlusive arterial disease after acute i.v. and medium term oral treatment. Prostacyclin (as 6- keto-PGF_1alpha) and PGE ₂ plasma concentrations have been measured together with arterial blood flow, peripheral vascular resistance, platelet aggregation and red blood cell deformability. Pentoxifylline was found both in healthy sub jects and patients to significantly increase prostacyclin plasma concentration after i.v. treatment. In medium term oral treatment prostacyclin concentration was found to increase only two hours after administration and not 8 hours after. No significant variations in PGE₂ plasma concentration were found at any time in both groups. Pentoxifylline significantly enhanced resting and post-ischemic blood flow of the lower limbs and simultaneously decreased peripheral vascular resistance both in healthy subjects and patients. Different grades of delayed platelet aggregation and increased red blood cell deformability were also ob served.

In conclusion results of the present placebo controlled study show that pen toxifylline increases arterial blood flow in patients with occlusive arterial dis ease. Moreover pentoxifylline induces a temporary stimulation of prostacyclin synthesis which can be suggested to contribute to the clinical activity of the drug as far as an antithrombotic effect in terms of inhibition of platelet aggregation is concerned.

Angiology, Vol. 36, No. 9, 628-637 (1985)
DOI: 10.1177/000331978503600907


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				W. Wang, E. Zolty, S. Falk, V. Basava, L. Reznikov, and R. Schrier Pentoxifylline protects against endotoxin-induced acute renal failure in mice Am J Physiol Renal Physiol, November 1, 2006; 291(5): F1090 - F1095. [Abstract] [Full Text] [PDF]

				K.-H. Staubach, J. Schroder, F. Stuber, K. Gehrke, E. Traumann, and P. Zabel Effect of Pentoxifylline in Severe Sepsis: Results of a Randomized, Double-blind, Placebo-Controlled Study Arch Surg, January 1, 1998; 133(1): 94 - 100. [Abstract] [Full Text] [PDF]

				C. Corsi, M. Pollastri, E. Marrapodi, D. Leanza, S. Giordano, and S. D'Iddio L-Propionylcarnitine Effect on Postexercise and Postischemic Hyperemia in Patients Affected by Peripheral Vascular Disease Angiology, August 1, 1995; 46(8): 705 - 713. [Abstract] [PDF]

				M. De Felice, P. Gallo, and G. Masotti Current Therapy of Peripheral Obstructive Arterial Disease. The Non-Surgical Approach Angiology, January 1, 1990; 41(1): 1 - 11. [Abstract] [PDF]

				G. Rudofsky, K.F. Haussler, H.P. Kunkel, H. Schneider-May, F. Spengel, O. Symann, and H.-J. Werner Intravenous Treatment of Chronic Peripheral Occlusive Arterial Disease: A Double-Blind, Placebo-Controlled, Randomized, Multicenter Trial of Pentoxifylline Angiology, July 1, 1989; 40(7): 639 - 649. [Abstract] [PDF]

				R. S. Yessenow and M. D. Maves The Effects of Pentoxifylline on Random Skin Flap Survival Arch Otolaryngol Head Neck Surg, February 1, 1989; 115(2): 179 - 181. [Abstract] [PDF]

				R. Testa, A. Biagini, C. Michelassi, M. Emdin, M. G. Mazzei, C. Carpeggiani, and A. l'Abbate Improvement of Walking Distance in Patients with Intermittent Claudication by Chronic Local Therapy with Isosorbide Dinitrate Ointment Angiology, January 1, 1988; 39(1): 1 - 7. [Abstract] [PDF]