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Angiology
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Somatostatin and Peripheral Blood Flow in Man

Luigi Savi

Catholic University of the Sacred Heart, Department of Internal Medicine, Rome, Italy

Carmine Cardillo

Catholic University of the Sacred Heart, Department of Internal Medicine, Rome, Italy

Giuseppe Bombardieri

Catholic University of the Sacred Heart, Department of Internal Medicine, Rome, Italy

Somatostatin (SS), a physiological substance which inhibits secretion of GH, TSH, glucagon and insulin, was evaluated as a vasoactive agent.

In normal and arteriopatic subjects SS was administered intravenously by bolus for 3 minutes and by infusion for 30 minutes.

Rheography and plethysmography of lower limbs were performed before, during and after somatostatin administration.

A marked improvement of blood flow, provoked by somatostatin, was ob served. A reduction of heart rate was also observed.

Some hypotheses about the mechanism with which SS acts upon peripheral circulation are discussed.

Angiology, Vol. 36, No. 8, 511-515 (1985)
DOI: 10.1177/000331978503600806
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