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Essential Hypertension: A Metabolic Cause? A HypothesisDepartment of Cardiology, Sta. Maria University Hospital, Lisboa, Portugal
Department of Cardiology, Sta. Maria University Hospital, Lisboa, Portugal
Department of Cardiology, Sta. Maria University Hospital, Lisboa, Portugal Forty-five hypertensive patients, 28 women and 17 men, age range between 35 and 65 years (mean 50 years), with blood pressures which current therapy did not succeed to control, were submitted to several examinations in order to identify the cause of their hypertension. We found isolated or combinated ab normal values of aldosterone, renin, calcium and or potassium as the only alter ations in 19 patients. We distinguished 4 groups descretionarily classified according to biochemical alterations: renin and aldosterone increase, renin in crease, aldosterone increase, calcium and or potassium reduction. The therapy used, intentionally aimed at the correction of the biochemical alterations found. Normal blood pressure was achieved in all patients and si multaneously the biochemical alterations also became normal in patients with isolated hyperreninemia, with combined hyperreninemia and hyperaldos teronemia and in those with hypocalcemia and or hypopotassemia. In patients were only isolated hyperaldosteronemia was found, this condition returned to normal in all except one. We suggest that besides the disturbances in sodium distribution other elec trolytes or biochemical alterations may also play an equally important role in regulating, and sustaining essential hypertension.
Angiology, Vol. 36, No. 5,
305-309 (1985) |
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