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Angiology
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Biochemical Analysis of Dermal Connective Tissue in Subjects Affected by Primary Uncomplicated Varicose Veins

Lupo Andreotti

From the Istituto di Clinica Medica e Terapia Medica, Rheumatology, Florence, Italy

Daniele Cammelli

From the Istituto di Clinica Medica e Terapia Medica , Florence, Italy

Salvatore Sampognaro

From the Istituto di Clinica Medica e Terapia Medica , Florence, Italy

Andrea Allori

From the Istituto di Clinica Medica e Terapia Medica , Florence, Italy

Daniele Baldoni

From the Istituto di Clinica Medica e Terapia Medica , Florence, Italy

Alessandro Bussotti

From the Istituto di Clinica Medica e Terapia Medica , Florence, Italy

Paolo Cortini

From the Istituto di Clinica Chirurgica , Florence, Italy

Francesco Di Giovine

From the Istituto di Clinica Medica e Terapia Medica , Florence, Italy

Gaetana Sterrantino

From the Istituto di Clinica Medica e Terapia Medica , Florence, Italy

Biochemical analysis of dermal connective tissue was carried out in 14 sub jects affected by primary uncomplicated varicose veins and 14 controls. Skin samples were taken, according to fixed criteria, from operation pieces of total mastectomy for breast cancer.

The results suggest that the dermal tissue in these subjects is just thinner than that of controls, confirming previous similar clinical findings.

The elective reduction of the collagen content observed, unassociated with changes of other components of the dermal connective tissue, brings evidence for a systemic biochemical defect of the extracellular matrix i.e. a collagen de fect affecting the entire body structure and not only the varicose or pre-varicose veins of the lower limbs.

Angiology, Vol. 36, No. 5, 265-270 (1985)
DOI: 10.1177/000331978503600501
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