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Thrombocytopenia and Lupus-Like Anticoagulant in a Patient with Peripheral Vascular Disease: Response to Infusion of Prostacyclin

From the Metabolic Unit, Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, England

D.P. Mikhailidis

From the Metabolic Unit, Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, England

F. Boag

From the Metabolic Unit, Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, England

M.A. Barradas

From the Metabolic Unit, Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, England

J.Y. Jeremy

From the Metabolic Unit, Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, England

L. Gracey

From the Department of Surgery, Royal Free Hospital and School of Medicine, London, England

P. Dandona

From the Metabolic Unit, Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, England

A 46 year old man with intermittent claudication due to severe peripheral vascular disease had a circulating lupus like anticoagulant (LLAC), thrombocy topenia (79 x 10⁹/₁), markedly reduced platelet survival and a normal bone mar row. He was treated with intravenous prostacyclin (PGI ₂) infusions which resulted in improvement of the patient's exercise tolerance and normalisation of his platelet count (300 x 10⁹/ ₁) and platelet aggregation could then be assessed. The platelets were markedly hyperaggregable and generated supranormal quantities of thromboxane A₂. A diagnosis of consumptive thrombocytopenia secondary to peripheral vascular disease and platelet hyperaggregability was made. Despite therapy with aspirin and dipyridamole, gradual and progressive reduction in platelet count followed and his exercise tolerance declined over the next three months. Immunoglobulin prepared from the patient's serum did not inhibit vascular PGI₂ synthesis in vitro.

To our knowledge this is the first reported case of consumptive thrombocyto penia due to severe peripheral vascular disease and platelet hyperaggregability. PGI₂ administration caused a transient resolution of these features which was not sustained by aspirin and dipyridamole.

Angiology, Vol. 36, No. 4, 258-263 (1985)
DOI: 10.1177/000331978503600409


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