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Angiology
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Buflomedil in Arterial Occlusive Disease: Results of a Controlled Multicenter Study

G. Trübestein

Medizinische Universitäts-Poliklinik, Bonn, Federal Republic of Germany

K. Balzer

Evangelisches Krankenhaus Mülheim, Rühr, Federal Republic of Germany

H. Bisler

Knappschaftskrankenhaus Bottrop, Bottrop, Federal Republic of Germany

N. Klüken

Abteilung fur Dermatologie und Angiologie der Universitäts-Kliniken Essen, Essen, Federal Republic of Germany

H. Muller-Wiefel

Johannes-Hospital Duisburg, Duisburg, Federal Republic of Germany

B. Unkel

Marienhospital y Gelsenkirchen, Gelsenkirchen, Federal Republic of Germany

Y. Mahfoud

Marienhospital y Gelsenkirchen, Gelsenkirchen, Federal Republic of Germany

W. Ziegler

Institut für Forschungsplanung - CH Bettingen-Basel, Switzerland

In a double-blind, randomised multicentre study buflomedil, a vasoactive substance, was compared with placebo in the treatment of 93 patients with chronic arterial occlusive disease. After a run-in period of four weeks the patients received either buflomedil (600 mg daily) or placebo over 12 weeks. The pain-free and the total walking distances improved significantly in both groups. However, the differences in the improvement between the two groups were highly signifi cant and in favour of buflomedil: for the pain-free walking distance p<0.001 and for the total walking distance p<0.01.

The results indicate that buflomedil has a beneficial effect on the symptoms and lengthens the walking distance in patients with arterial occlusive disease.

Angiology, Vol. 35, No. 8, 500-505 (1984)
DOI: 10.1177/000331978403500805
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