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Mitral Valve Prolapse and Spasm of Normal Coronary Arteries: Report of Four Cases and Review of the Literature

Division of Cardiovascular Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts

Jang B. Singh

Nancy Jarvais

Eileen Adams

Kevin Erkkila

The association between mitral valve prolapse (MVP) and atypical chest pain has been well-described. Numerous theories have been proposed to explain this association. A number of lines of evidence suggest that underlying ischemia may cause chest pain in some patients with MVP. We have recently evaluated 4 patients with chest pain syndromes who had angiographic evidence of MVP and spasm of angiographically normal coronary arteries. The possibility that coro nary spasm is the underlying etiology of chest pain in some patients with mitral valve prolapse raises a theoretical argument against ß-blockade in these patients. Three of our patients were successfully treated with calcium channel blockers.

Angiology, Vol. 35, No. 5, 300-307 (1984)
DOI: 10.1177/000331978403500506


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