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Hypertensive Crisis Induced by Metoclopramide in Patient with PheochromocytomaFrom the Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka, Japan
Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University, Kyushu, Japan
Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University, Kyushu, Japan A hypertensive crisis associated with evidence of catecholamine release was induced following intravenous administration of 10 mg metoclopramide in a woman with pheochromocytoma and in whom the tyramine test was nega tive. After removal of the tumor, blood-pressure and plasma catecholamine concentrations were not influenced by the administration of metoclopramide. It is suggested that the mechanism of hypertensive crises induced by metoclo pramide may not be due to a direct catecholamine releasing effect from the tumor or sympathetic nerve endings, but rather to its presynaptic dopaminer gic blocking effect which would indirectly release catecholamines.
Angiology, Vol. 35, No. 2,
122-128 (1984) This article has been cited by other articles:
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