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Angiology
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Hypertensive Crisis Induced by Metoclopramide in Patient with Pheochromocytoma

Masayoshi Abe

From the Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka, Japan

Yasuhiko Orita

Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University, Kyushu, Japan

Yasuhide Nakashima

Motoomi Nakamura

Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University, Kyushu, Japan

A hypertensive crisis associated with evidence of catecholamine release was induced following intravenous administration of 10 mg metoclopramide in a woman with pheochromocytoma and in whom the tyramine test was nega tive.

After removal of the tumor, blood-pressure and plasma catecholamine concentrations were not influenced by the administration of metoclopramide. It is suggested that the mechanism of hypertensive crises induced by metoclo pramide may not be due to a direct catecholamine releasing effect from the tumor or sympathetic nerve endings, but rather to its presynaptic dopaminer gic blocking effect which would indirectly release catecholamines.

Angiology, Vol. 35, No. 2, 122-128 (1984)
DOI: 10.1177/000331978403500209


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This article has been cited by other articles:


Home page
J Intensive Care MedHome page
C. V. S. Ram and D. Hyman
Hypertensive Crises
J Intensive Care Med, May 1, 1987; 2(3): 151 - 162.
[Abstract] [PDF]



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