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Angiology
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*PHENOXYBENZAMINE
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*Raynaud's Disease
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Therapeutic Efficacy of Alpha-Adrenoceptor Blockade in Primary and Secondary Raynaud's Syndrome

Ton J.M. Cleophas

From the Department of Medicine, University of Nijemegen, The Netherlands

Henk J.J. van Lier

From the Department of Statistical Consultation, University of Nijmegen, The Netherlands

Peter Faaber

From the Department of Medicine, University of Nijemegen, The Netherlands

Jan F.M. Fennis

From the Department of Medicine, University of Nijemegen, The Netherlands

Albert van 't Laar

From the Department of Medicine, University of Nijemegen, The Netherlands

Twenty patients with primary and 11 with secondary Raynaud's syndrome were treated with the alpha-adrenoceptor blocker phenoxybenzamine (10-20 mg daily). In the secondary group mean age and mean duration of symptoms as well as presence of positive ANA and positive Clq blinding test were signifi cantly higher than in the primary group. In both groups a beneficial effect of the medication on finger temperature 12 min after finger cooling and on clinical symptoms was established. Secondary Raynaud's syndrome reacted at least as well as primary syndrome.

Angiology, Vol. 35, No. 11, 719-723 (1984)
DOI: 10.1177/000331978403501105
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




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