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Angiology
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The Effectiveness of Isoxsuprine in Patients With Intermittent Claudication

S.H. Skotnicki

From the Clinical Vascular Laboratory, Institute of Thoracic and Cardiovascular Surgery, Sint Radboud University Hospital, Nijmegen, The Netherlands

G. van Gaal

From the Clinical Vascular Laboratory, Institute of Thoracic and Cardiovascular Surgery, Sint Radboud University Hospital, Nijmegen, The Netherlands

P.F.F. Wijn

From the Clinical Vascular Laboratory, Institute of Thoracic and Cardiovascular Surgery, Sint Radboud University Hospital, Nijmegen, The Netherlands

Sixty male patients with intermittent claudication were investigated in a ran domized, double-blind, placebo-controlled study in order to determine the ef fectiveness of Isoxsuprine.

The analysis of the results was made on the basis of subjective assessment of symptoms by the patients themselves and also on the results of segmental blood- pressure measurements and ankle/arm indices at rest and after standardised exercise.

Significant differences were demonstrated between the active and placebo groups as regards pain-free walking distance although arterial pressure mea surements did not show statistically significant differences between the two groups.

Isoxsuprine appears to be significantly beneficial only for patients with ob structions at the femoro-popliteal level.

Angiology, Vol. 35, No. 11, 685-693 (1984)
DOI: 10.1177/000331978403501101
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