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Angiology
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Ineffectiveness of Ca2+-Antagonists Nicardipine and Diltiazem on Experimental Atherosclerosis in Cholesterol-fed Rabbits

Michitaka Naito

Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan

Fumio Kuzuya

Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan

Kan-ichi Asai

Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan

Kazuaki Shibata

Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan

Noboru Yoshimine

Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan

There is accumulating evidence that calcium metabolism plays an important role in the pathogenesis of atherosclerosis. The inhibitory effect of nifedipine, a Ca2-antagonist, on experimental atherosclerosis in cholesterol-fed rabbits has been reported, and we examined the anti-atherosclerotic action of nicardipine and diltiazem, similar Ca2+-antagonists, but no inhibitory action was observed.

It is necessary to recognize the fact that the sensitivity of rabbits to an antiatherogenic diet shows great individual differences. For the purpose of preventing atherosclerosis due to the abnormality of lipid metabolism the use of Ca2+-antagonist is not warranted at the present stage.

Angiology, Vol. 35, No. 10, 622-627 (1984)
DOI: 10.1177/000331978403501002
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This article has been cited by other articles:


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 ANGIOLOGYHome page
R. Gasser
Calcium Antagonists: Pharmacologic Agents in Search of New Clinical Indications
Angiology, January 1, 1990; 41(1): 36 - 43.
[Abstract] [PDF]

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 VASC ENDOVASCULAR SURGHome page
M. Naito, K. Asai, K. Shibata, M. Kuzuya, C. Funaki, and F. Kuzuya
The Effect of Diltiazem on Experimental Intimal Thickening Caused by Common Carotid Artery Investment in Rabbits
Vascular and Endovascular Surgery, September 1, 1986; 20(5): 307 - 313.
[Abstract] [PDF]


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